PhD positions available deadline 15th July 2018

Project title: Programmable Enzymatic Synthesis of Bioactive Compounds

The aim of this project is to devise a conceptually novel and general platform that will deliver a step-change in complexity of de novo biosynthetic pathways by moving from manual to automated design, build and test. We have identified three bottlenecks that will need to be overcome to build an effective ProgES platform i. Increasing the diversity of structures accessible through biocatalysis by incorporation of C-H activation for early and late stage functionalisation. ii. Fast analytical methods to improve throughput and timescale. iii. A dedicated bioinformatics platform that can harness the technology already developed for chemical and biochemical synthesis and incorporate them into an effective tool for automation for de novo biosynthesis. As proof of principle the ProgrES platform will be used to generate a diverse library of imino sugars of unprecedented complexity.

Contact for further Information: Professor Sabine Flitsch: Sabine.Flitsch@manchester.ac.uk

Find out more and apply here.

Research Associate Positions (2 posts): closing date 19/06/2018

Job Reference: S&E-12054

Closing Date: 19/06/2018

Salary: £31,604 to £38,833 per annum

Employment Type: Fixed Term

Faculty / Organisational Unit: Science & Engineering

Hours Per week: Full time

Contract Duration: Available from 1 July 2018 to 31 August 2019 with option of extension

Two Postdoctoral Research Associate positions under the supervision of Professor Sabine Flitsch are available for outstanding and ambitious scientists to join a multidisciplinary team of scientists working as part of a project (ProgES) on developing programmable de novo enzymatic pathways. The project will bring together scientists with chemical, analytical, biochemical and bioinformatics background. We are now looking for candidates with one or more of the following areas of expertise: synthetic chemistry; analytical chemistry, in particular mass spectrometry; bioinformatics including database design and/or modelling.

You should have a PhD or equivalent in one of these areas: chemistry, biochemistry, analytical chemistry, bioinformatics. You should have a track-record of published work, be capable of working under your own initiative and be able to provide day-to-day supervision for PhD students associated with the project. Excellent communication and organisational skills are also required.

Further details and how to apply can be found here.